CGA-N12, a peptide derived from chromogranin A, promotes apoptosis of Candida tropicalis by attenuating mitochondrial functions
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Chromogranin A (CgA) References
"There appears to be a direct correlation between tumor burden and serum CgA levels. Rising serum levels of CgA can predeed radiographic evidence of recurrence. . . . .Using serum CgA level above 30 U/ml, one is able to discriminate between disease free patients and those with recurrent metastatic disease with a sensitivity of 92% and specificity of 96%. This is superior to measuring urinary 5-...
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Candida species (Candida spp.) are important fungal pathogens, which cause numerous clinical diseases associated with significant mortality and morbidity in healthcare settings. In our previous study, we identified a recombinant peptide, chromogranin A (CGA)-N46, corresponding to the N-terminal Pro31-Gln76 sequence of human CGA, that exhibited antifungal activity against Candida albicans. The p...
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Introduction: Adrenal tumours can produce specific hormones and cause characteristic symptoms. The majority of adrenal incidentalomas are clinically silent, but some may be malignant or pose other potential threats to life. Chromogranin A (CgA) is the main, nonspecific marker of neuroendocrine tumours (NET). In the adrenals, CgA is produced by chromaffin cells localised in the adrenal medulla. ...
متن کاملCgA344-364) is a vasoreactive and anti-hypertensive peptide derived from Chromogranin A (CgA). Using the isolated avascular frog heart as a bioassay, in which the interactions
Corresponding Author: *S. K. Mahata, Department of Medicine, University of California & VA San Diego Healthcare System, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0838 USA. Tel: (858)552-8585, x2637; Fax: (858)642-6425; email: [email protected] or *Bruno Tota, Department of Cell Biology University of Calabria 87030 Arcavacata di Rende (CS) Italy. Phone. +39-0984-492907; Fax: +39-0984492906...
متن کاملProtoplasts Obtained from Candida tropicalis
A method for the preparation of protoplasts from Candida tropicalis cultivated on n-tetradecane is described. This essentially consists of replacing the mannitolsorbitol solution of the classical helicase technique by 1 M magnesium sulfate and lowering the pH to 4.1 during incubation in the presence of helicase. The protoplasts thus prepared behave like intact cells and are capable of consuming...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2018
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bcj20170894